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dc.contributor.authorAlegret, Nuria
dc.contributor.authorDominguez-Alfaro, Antonio
dc.contributor.authorMecerreyes Molero, David
dc.date.accessioned2020-07-01T10:13:30Z
dc.date.available2020-07-01T10:13:30Z
dc.date.issued2019-01-14
dc.identifier.citationBiomacromolecules 20(1) : 73-89 (2019)es_ES
dc.identifier.issn1525-7797
dc.identifier.urihttp://hdl.handle.net/10810/44788
dc.descriptionUnformatted postprint.es_ES
dc.description.abstract3D scaffolds appear to be a cost-effective ultimate answer for biomedical applications, facilitating rapid results while providing an environment similar to in vivo tissue. These biomaterials offer large surface areas for cell or biomaterial attachment, proliferation, biosensing and drug delivery applications. Among 3D scaffolds, the ones based on conjugated polymers (CPs) and natural nonconductive polymers arranged in a 3D architecture provide tridimensionality to cellular culture along with a high surface area for cell adherence and proliferation as well electrical conductivity for stimulation or sensing. However, the scaffolds must also obey other characteristics: homogeneous porosity, with pore sizes large enough to allow cell penetration and nutrient flow; elasticity and wettability similar to the tissue of implantation; and a suitable composition to enhance cell− matrix interactions. In this Review, we summarize the fabrication methods, characterization techniques and main applications of conductive 3D scaffolds based on conductive polymers. The main barrier in the development of these platforms has been the fabrication and subsequent maintenance of the third dimension due to challenges in the manipulation of conductive polymers. In the last decades, different approaches to overcome these barriers have been developed for the production of conductive 3D scaffolds, demonstrating a huge potential for biomedical purposes. Finally, we present an overview of the emerging strategies developed to manufacture 3D conductive scaffolds, the techniques used to fully characterize them, and the biomedical fields where they have been applied.es_ES
dc.description.sponsorshipThis project has received funding from the European Union’s Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant agreement No 753293, acronym NanoBEAT, and European Research Council by Starting Grant Innovative Polymers for Energy Storage (iPes) 306250.es_ES
dc.language.isoenges_ES
dc.publisherACS Publicationses_ES
dc.relationinfo:eu-repo/grantAgreement/EC/H2020/753293es_ES
dc.relationinfo:eu-repo/grantAgreement/EC/FP7/306250es_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectpolypyrrolees_ES
dc.subjectPEDOTes_ES
dc.subjectPANies_ES
dc.subjectbiomedical applicationses_ES
dc.subjecttissue engineeringes_ES
dc.subjectdrug deliveryes_ES
dc.subjectelectric stimulationes_ES
dc.subjectconjugated polymerses_ES
dc.title3D Scaffolds Based on Conductive Polymers for Biomedical Applicationses_ES
dc.typeinfo:eu-repo/semantics/reviewes_ES
dc.rights.holder© 2019 American Chemical Societyes_ES
dc.relation.publisherversionhttps://pubs.acs.org/doi/10.1021/acs.biomac.8b01382es_ES
dc.identifier.doi10.1021/acs.biomac.8b01382
dc.contributor.funderEuropean Commission
dc.departamentoesCiencia y tecnología de polímeroses_ES
dc.departamentoeuPolimeroen zientzia eta teknologiaes_ES


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