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dc.contributor.authorAlegret, Nuria
dc.contributor.authorDominguez-Alfaro, Antonio
dc.contributor.authorGonzález-Domínguez, Jose M.
dc.contributor.authorArnaiz, Blanca
dc.contributor.authorCossío, Unai
dc.contributor.authorBosi, Susanna
dc.contributor.authorVázquez, Ester
dc.contributor.authorRamos Cabrer, Pedro
dc.contributor.authorMecerreyes Molero, David
dc.contributor.authorPrato, Maurizi
dc.date.accessioned2020-07-01T10:33:49Z
dc.date.available2020-07-01T10:33:49Z
dc.date.issued2018-12-19
dc.identifier.citationACS Applied Materials & Interfaces 10(50) : 43904-43914 (2018)es_ES
dc.identifier.issn1944-8244
dc.identifier.urihttp://hdl.handle.net/10810/44789
dc.descriptionUnformatted post printes_ES
dc.description.abstractThree-dimensional scaffolds for cellular organization need to enjoy a series of specific properties. On the one hand, the morphology, shape and porosity are critical parameters and eventually related with the mechanical properties. On the other hand, electrical conductivity is an important asset when dealing with electroactive cells, so it is a desirable property even if the conductivity values are not particularly high. Here, we construct three-dimensional (3D) porous and conductive composites, where C8-D1A astrocytic cells were incubated to study their biocompatibility. The manufactured scaffolds are composed exclusively of carbon nanotubes (CNTs), a most promising material to interface with neuronal tissue, and polypyrrole (PPy), a conjugated polymer demonstrated to reduce gliosis, improve adaptability, and increase charge-transfer efficiency in brain-machine interfaces. We developed a new and easy strategy, based on the vapor phase polymerization (VPP) technique, where the monomer vapor is polymerized inside a sucrose sacrificial template containing CNT and an oxidizing agent. After removing the sucrose template, a 3D porous scaffold was obtained and its physical, chemical, and electrical properties were evaluated. The obtained scaffold showed very low density, high and homogeneous porosity, electrical conductivity, and Young’s Modulus similar to the in vivo tissue. Its high biocompatibility was demonstrated even after 6 days of incubation, thus paving the way for the development of new conductive 3D scaffolds potentially useful in the field of electroactive tissues.es_ES
dc.description.sponsorshipMP received funding from the Spanish Ministry of Economy and Competitiveness MINECO (project CTQ2016-76721-R), Diputación Foral de Gipuzkoa program Red (101/16) and ELKARTEK bmG2017 (Ref: Elkartek KK-2017/00008, BOPV resolution: 8 Feb 2018). NA has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No 753293, acronym NanoBEAT. We acknowledge Donato Mancino for the support given during the revision stage. As well, AXA Research Fund and University of Trieste are gratefully acknowledged.es_ES
dc.language.isoenges_ES
dc.publisherACS Publicationses_ES
dc.relationinfo:eu-repo/grantAgreement/EC/H2020/753293es_ES
dc.relationinfo:eu-repo/grantAgreement/MINECO/CTQ2016-76721-Res_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subject3D scaffoldes_ES
dc.subjectcarbon nanotubeses_ES
dc.subjectpolypyrrolees_ES
dc.subjectvapour phase polymerizationes_ES
dc.subjectconjugated polymerses_ES
dc.subjecttissue engineeringes_ES
dc.subjectneural prostheseses_ES
dc.titleThree-Dimensional Conductive Scaffolds as Neural Prostheses Based on Carbon Nanotubes and Polypyrrolees_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.holder© 2018 American Chemical Societyes_ES
dc.relation.publisherversionhttps://pubs.acs.org/doi/10.1021/acsami.8b16462es_ES
dc.identifier.doi10.1021/acsami.8b16462
dc.contributor.funderEuropean Commission
dc.departamentoesCiencia y tecnología de polímeroses_ES
dc.departamentoeuPolimeroen zientzia eta teknologiaes_ES


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