dc.contributor.author | Nyholm, Lasse | |
dc.contributor.author | Koziol, Adam | |
dc.contributor.author | Marcos Basagoiti, Sofia | |
dc.contributor.author | BoltBotnen, Amanda | |
dc.contributor.author | Aizpurua Arrieta, Ostaizka | |
dc.contributor.author | Gopalakrishnan, Shyam | |
dc.contributor.author | Limborg, Morten T. | |
dc.contributor.author | Thomas, M. | |
dc.contributor.author | Gilbert, P. | |
dc.contributor.author | Alberdi, Antton | |
dc.date.accessioned | 2020-11-03T11:05:05Z | |
dc.date.available | 2020-11-03T11:05:05Z | |
dc.date.issued | 2020-08-21 | |
dc.identifier.citation | iScience 23(8) : (2020) // Article ID 101414 | es_ES |
dc.identifier.issn | 2589-0042 | |
dc.identifier.uri | http://hdl.handle.net/10810/47624 | |
dc.description.abstract | From ontogenesis to homeostasis, the phenotypes of complex organisms are shaped by the bidirectional interactions between the host organisms and their associated microbiota. Current technology can reveal many such interactions by combining multi-omic data from both hosts and microbes. However, exploring the full extent of these interactions requires careful consideration of study design for the efficient generation and optimal integration of data derived from (meta)genomics, (meta) transcriptomics, (meta)proteomics, and (meta)metabolomics. In this perspective, we introduce the holo-omic approach that incorporates multi-omic data from both host and microbiota domains to untangle the interplay between the two. We revisit the recent literature on biomolecular host-microbe interactions and discuss the im-plementation and current limitations of the holo-omic approach. We anticipate that the application of this approach can contribute to opening new research avenues and discoveries in biomedicine, biotechnology, agricultural and aquacultural sciences, nature conservation, as well as basic ecological and evolutionary research. | es_ES |
dc.description.sponsorship | The authors thank the following for funding their research: The Danish National Research Foundation award to M.T.P.G. (DNRF143), Villum Fonden grant to M.T. P.G. (17417), Lundbeckfonden grant to A.A. (R250-2017-1351), Danish Council for Independent Research grants to A.A. (DFF 5051-00033) and M.T.L. (DFF 8022-00005), ERC Consolidator Grant toM. T.P.G. (681396-Extinction Genomics), The Norwegian Seafood Research Fund -FHF grant to M.T.P.G. and M.T.L. (901436-HoloFish), H2020 Marie Sklodowska-Curie Individual Fellowship grant toM.T.L. (745723-HappyFish) and the European Union's Horizon 2020 Research and Innovation Programme grant to M.T.P.G., A.A. and M.T.L. (Grant Agreement No 817729 -HoloFood). Furthermore, the authors would like to thank Rob Dunn for his input and discussions. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Cell Press | es_ES |
dc.relation | info:eu-repo/grantAgreement/EC/H2020/745723 | es_ES |
dc.relation | info:eu-repo/grantAgreement/EC/H2020/817729 | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.subject | wide association | es_ES |
dc.subject | gut microbiota | es_ES |
dc.subject | comparative genomics | es_ES |
dc.subject | sample-size | es_ES |
dc.subject | disease | es_ES |
dc.subject | promotes | es_ES |
dc.subject | metagenomics | es_ES |
dc.subject | probiotics | es_ES |
dc.subject | wolbachia | es_ES |
dc.subject | evolution | es_ES |
dc.title | Holo-Omics: Integrated Host-Microbiota Multi-omics for Basic and Applied Biological Research | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | This is an open access article distributed under the terms of the Creative Commons CC-BY license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | es_ES |
dc.rights.holder | Atribución 3.0 España | * |
dc.relation.publisherversion | https://www.sciencedirect.com/science/article/pii/S2589004220306040?via%3Dihub | es_ES |
dc.identifier.doi | 10.1016/j.isci.2020.101414 | |
dc.contributor.funder | European Commission | |
dc.departamentoes | Genética, antropología física y fisiología animal | es_ES |
dc.departamentoeu | Genetika,antropologia fisikoa eta animalien fisiologia | es_ES |