dc.contributor.author | Camarero Espinosa, Sandra | |
dc.contributor.author | Moroni, Lorenzo | |
dc.date.accessioned | 2021-03-04T09:23:21Z | |
dc.date.available | 2021-03-04T09:23:21Z | |
dc.date.issued | 2021-02-15 | |
dc.identifier.citation | Nature Communications 12(1) : (2021) // Article ID 1031 | es_ES |
dc.identifier.issn | 2041-1723 | |
dc.identifier.uri | http://hdl.handle.net/10810/50457 | |
dc.description.abstract | The application of physical stimuli to cell cultures has shown potential to modulate multiple cellular functions including migration, differentiation and survival. However, the relevance of these invitro models to future potential extrapolation invivo depends on whether stimuli can be applied "externally", without invasive procedures. Here, we report on the fabrication and exploitation of dynamic additive-manufactured Janus scaffolds that are activated on-command via external application of ultrasounds, resulting in a mechanical nanovibration that is transmitted to the surrounding cells. Janus scaffolds were spontaneously formed via phase-segregation of biodegradable polycaprolactone (PCL) and polylactide (PLA) blends during the manufacturing process and behave as ultrasound transducers (acoustic to mechanical) where the PLA and PCL phases represent the active and backing materials, respectively. Remote stimulation of Janus scaffolds led to enhanced cell proliferation, matrix deposition and osteogenic differentiation of seeded human bone marrow derived stromal cells (hBMSCs) via formation and activation of voltage-gated calcium ion channels | es_ES |
dc.description.sponsorship | The authors acknowledge the Texas A&M Health Science Center College of Medicine Institute for Regenerative Medicine at Scott & White who isolated and provided the cells through a grant from NCRR of the NIH (Grant #P40RR017447). The authors acknowledge the financial support from the European Commission under the ERC starting grant “Cell Hybridge” of the Horizon2020 framework program (Grant # 637308). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Nature | es_ES |
dc.relation | info:eu-repo/grantAgreement/EC/H2020/637308 | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.subject | physical stimuli | es_ES |
dc.subject | cell cultures | es_ES |
dc.subject | invitro models | es_ES |
dc.subject | Janus scaffolds | es_ES |
dc.subject | ultrasounds | es_ES |
dc.subject | mechanical nanovibration | es_ES |
dc.subject | surrounding cells | es_ES |
dc.title | Janus 3D Printed Dynamic Scaffolds for Nanovibration-Driven Bone Regeneration | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | This article is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0) | es_ES |
dc.rights.holder | Atribución 3.0 España | * |
dc.relation.publisherversion | https://www.nature.com/articles/s41467-021-21325-x | es_ES |
dc.identifier.doi | 10.1038/s41467-021-21325-x | |
dc.contributor.funder | European Commission | |
dc.departamentoes | Ciencia y tecnología de polímeros | es_ES |
dc.departamentoeu | Polimeroen zientzia eta teknologia | es_ES |