dc.contributor.author | Krukiewicz, Katarzyna | |
dc.contributor.author | Britton, James | |
dc.contributor.author | Wieclawska, Daria | |
dc.contributor.author | Skorupa, Malgorzata | |
dc.contributor.author | Fernández Hernández, Jorge | |
dc.contributor.author | Sarasua Oiz, José Ramón | |
dc.contributor.author | Biggs, Manus J. P. | |
dc.date.accessioned | 2021-03-10T13:22:59Z | |
dc.date.available | 2021-03-10T13:22:59Z | |
dc.date.issued | 2021-01-14 | |
dc.identifier.citation | Scientific Reports 11(1) : (2021) // Article ID 1295 | es_ES |
dc.identifier.issn | 2045-2322 | |
dc.identifier.uri | http://hdl.handle.net/10810/50537 | |
dc.description.abstract | By providing a bidirectional communication channel between neural tissues and a biomedical device, it is envisaged that neural interfaces will be fundamental in the future diagnosis and treatment of neurological disorders. Due to the mechanical mismatch between neural tissue and metallic neural electrodes, soft electrically conducting materials are of great benefit in promoting chronic device functionality. In this study, carbon nanotubes (CNT), silver nanowires (AgNW) and poly(hydroxymethyl 3,4-ethylenedioxythiophene) microspheres (MSP) were employed as conducting fillers within a poly(epsilon-decalactone) (EDL) matrix, to form a soft and electrically conducting composite. The effect of a filler type on the electrical percolation threshold, and composite biocompatibility was investigated in vitro. EDL-based composites exhibited favourable electrochemical characteristics: EDL/CNT-the lowest film resistance (1.2±0.3 kOmega), EDL/AgNW-the highest charge storage capacity (10.7±0.3 mC cm-2), and EDL/MSP-the highest interphase capacitance (1478.4±92.4Fcm-2). All investigated composite surfaces were found to be biocompatible, and to reduce the presence of reactive astrocytes relative to control electrodes. The results of this work clearly demonstrated the ability of high aspect ratio structures to form an extended percolation network within a polyester matrix, resulting in the formulation of composites with advantageous mechanical, electrochemical and biocompatibility properties. | es_ES |
dc.description.sponsorship | This publication has emanated from research conducted with the financial support of Science Foundation Ireland and is co-funded under the European Regional Development Fund under Grant Number 13/RC/2073. This project has received funding from the European Union's Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 713690 and SFI Technology Innovation Development Programme, Grant no. 15/TIDA/2992. This research has received funding from the National University of Ireland, Galway, Hardiman PhD scholarship 2016-2020. This work has been supported by the Polish National Science Centre (SONATA-2016/23/D/ST5/01306 and OPUS-2019/35/B/ST5/00995) and the Silesian University of Technology, Poland (04/040/BK_20/0113). This work has also received funding from the Basque Government GV/EJ (Department of Education, Linguistic Politics and Culture) through the consolidated research groups project IT927-16 (UPV/EHU, GIC/152), and a postdoctoral grant for J. F. from the University of the Basque Country (UPV/EHU). The authors acknowledge the facilities and scientific and technical assistance of the Centre for Microscopy & Imaging at the National University of Ireland Galway, a facility that is funded by NUIG and the Irish Government's Programme for Research in Third Level Institutions, Cycles 4 and 5, National Development Plan 2007-2013 | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Nature | es_ES |
dc.relation | info:eu-repo/grantAgreement/EC/H2020/713690 | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.subject | neural interfaces | es_ES |
dc.subject | neurological disorders | es_ES |
dc.subject | electrical percolation | es_ES |
dc.subject | composite biocompatibility | es_ES |
dc.subject | reactive astrocytes | es_ES |
dc.subject | control electrodes | es_ES |
dc.subject | polyester matrix | es_ES |
dc.title | Electrical Percolation in Extrinsically Conducting, Poly(εpsilon-Decalactone) Composite Neural Interface Materials | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | This article is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0) | es_ES |
dc.rights.holder | Atribución 3.0 España | * |
dc.relation.publisherversion | https://www.nature.com/articles/s41598-020-80361-7 | es_ES |
dc.identifier.doi | 10.1038/s41598-020-80361-7 | |
dc.contributor.funder | European Commission | |
dc.departamentoes | Ingeniería Minera y Metalúrgica y Ciencia de los Materiales | es_ES |
dc.departamentoeu | Meatze eta metalurgia ingeniaritza materialen zientzia | es_ES |