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dc.contributor.authorDíaz López, Andrés
dc.contributor.authorPaz Graniel, Indira
dc.contributor.authorRuiz, Verónica
dc.contributor.authorToledo, Estefanía
dc.contributor.authorBecerra Tomás, Nerea
dc.contributor.authorCorella, Dolores
dc.contributor.authorCastañer, Olga
dc.contributor.authorMartínez Hernández, José Alfredo
dc.contributor.authorAlonso Gómez, Ángel María ORCID
dc.contributor.authorWärnberg, Julia
dc.contributor.authorVioque, Jesús
dc.contributor.authorRomaguera, Dora
dc.contributor.authorLópez Miranda, José
dc.contributor.authorEstruch, Ramón
dc.contributor.authorTinahones, Francisco J.
dc.contributor.authorLapetra, José
dc.contributor.authorSerra Majem, Lluís
dc.contributor.authorBueno Cavanillas, Aurora
dc.contributor.authorTur, Josep A.
dc.contributor.authorMartín Sánchez, Vicente
dc.contributor.authorPintó, Xavier
dc.contributor.authorDelgado Rodríguez, Miguel
dc.contributor.authorMatía Martín, Pilar
dc.contributor.authorVidal, Josep
dc.contributor.authorVázquez, Clotilde
dc.contributor.authorDaimiel, Lidia
dc.contributor.authorFernández Villa, Tania
dc.contributor.authorRos, Emilio
dc.contributor.authorEguaras, Sonia
dc.contributor.authorBabio, Nancy
dc.contributor.authorSorli, José Vicente
dc.contributor.authorGoday, Albert
dc.contributor.authorAbete, Itziar
dc.contributor.authorTojal Sierra, Lucas
dc.contributor.authorBarón López, Francisco Javier
dc.contributor.authorTorres Collado, Laura
dc.contributor.authorMorey, Marga
dc.contributor.authorGarcía Ríos, Antonio
dc.contributor.authorCasas, Rosa
dc.contributor.authorBernal López, María Rosa
dc.contributor.authorSantos Lozano, José Manuel
dc.contributor.authorNavarro, Adela
dc.contributor.authorGonzález, José I.
dc.contributor.authorZomeño Fajardo, María Dolores
dc.contributor.authorZulet, M. Ángeles
dc.contributor.authorVaquero Luna, Jessica
dc.contributor.authorRamallal, Raúl
dc.contributor.authorFitó, Montserrat
dc.contributor.authorSalas Salvadó, Jordi
dc.date.accessioned2021-05-21T07:27:24Z
dc.date.available2021-05-21T07:27:24Z
dc.date.issued2021-03-31
dc.identifier.citationScientific Reports 11(1) : (2021) // Article ID 8719es_ES
dc.identifier.issn2045-2322
dc.identifier.urihttp://hdl.handle.net/10810/51515
dc.description.abstractIt remains unclear whether caffeinated beverages could have deleterious renal effects in elderly population with underlying comorbid conditions. We investigated the associations between coffee, tea, or caffeine intake and 1-year changes in glomerular filtration rate (eGFR) in a large Spanish cohort of overweight/obese elderly with metabolic syndrome (MetS). This prospective analysis includes 5851 overweight/obese adults (55–75 years) with MetS from the PREDIMED-Plus study. We assessed coffee, tea, and caffeine consumption from a validated food-frequency questionnaire and creatinine-based eGFR using the Chronic Kidney Disease Epidemiology Collaboration equation. Multivariate-adjusted regression models were applied to test associations between baseline coffee, tea, or caffeine intake and 1-year eGFR changes. Caffeinated coffee (> 2 cups/day) and tea (at least 1 cup/day) drinkers had 0.88 and 0.93 mL/min/1.73 m2 greater eGFR decrease respectively, compared to those with less than 1 cup/day of coffee consumption or non-tea drinkers. Furthermore, caffeinated coffee consumption of > 2 cups/day was associated with 1.19-fold increased risk of rapid eGFR decline > 3 mL/min/1.73 m2 (95% CI 1.01–1.41). Similarly, individuals in the highest (median, 51.2 mg/day) tertile of caffeine intake had a 0.87 mL/min/1.73 m2 greater eGFR decrease. Decaffeinated coffee was not associated with eGFR changes. In conclusion, higher consumption of caffeinated coffee, tea, and caffeine was associated with a greater 1-year eGFR decline in overweight/obese adults with MetS.es_ES
dc.description.sponsorshipTis work was supported by the ofcial Spanish Institutions for funding scientifc biomedical research, CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN) and Instituto de Salud Carlos III (ISCIII), through the Fondo de Investigación para la Salud (FIS), which is co-funded by the European Regional Development Fund (fve coordinated FIS projects leaded by JS-S and JVi, including the following projects: PI13/00673, PI13/00492, PI13/00272, PI13/01123, PI13/00462, PI13/00233, PI13/02184, PI13/00728, PI13/01090, PI13/01056, PI14/01722, PI14/00636, PI14/00618, PI14/00696, PI14/01206, PI14/01919, PI14/00853, PI14/01374, PI14/00972, PI14/00728, PI14/01471, PI16/00473, PI16/00662, PI16/01873, PI16/01094, PI16/00501, PI16/00533, PI16/00381, PI16/00366, PI16/01522, PI16/01120, PI17/00764, PI17/01183, PI17/00855, PI17/01347, PI17/00525, PI17/01827, PI17/00532, PI17/00215, PI17/01441, PI17/00508, PI17/01732, PI17/00926, PI19/00957, PI19/00386, PI19/00309, PI19/01032, PI19/00576, PI19/00017, PI19/01226, PI19/00781, PI19/01560, PI19/01332, PI20/01802, PI20/00138, PI20/01532, PI20/00456, PI20/00339, PI20/00557, PI20/00886, PI20/01158); the Especial Action Project entitled: Implementación y evaluación de una intervención intensiva sobre la actividad física Cohorte PREDIMED-Plus Grant to JS-S; the European Research Council (Advanced Research Grant 2014–2019; Agreement #340918) granted to MÁM-G.; the Recercaixa (Number 2013ACUP00194) grant to JS-S; grants from the Consejería de Salud de la Junta de Andalucía (PI0458/2013, PS0358/2016, PI0137/2018); the PROMETEO/2017/017 grant from the Generalitat Valenciana; the SEMERGEN grant; funds from the European Regional Development Fund (CB06/03); International Nut & Dried Fruit Council – FESNAD (Long-term efects of an energy-restricted Mediterranean diet on mortality and cardiovascular disease 2014 –2015, No. 201302) (PI: MÁM-G); the AstraZeneca Young Investigators Award in Category of Obesity and T2D 2017 (PI: DR); grant of support to research groups no. 35/2011 (Balearic Islands Gov.; FEDER funds) (JAT and CB); the JR17/00022 (ISCIII) grant to OC; the Boosting young talent call grant program for the development of IISPV research projects 2019–2021 (Ref.: 2019/IISPV/03 grant to AD-L); the Societat Catalana d’Endocrinologia i Nutrició (SCEN) Clinical-Research Grant 2019 (IPs: JS-S and AD-L). Collaborative Nutrition and/or Obesity Project for Young Researchers 2019 supported by CIBEROBN entitled: Lifestyle Interventions and Chronic Kidney Disease: Infammation, Oxidative Stress and Metabolomic Profle (LIKIDI study) grant to AD-L. IP-G receives a grant from the Spanish Ministry of Education, Culture and Sports (FPU17/01925). Jordi Salas-Salvadó, the senior author of this work, gratefully acknowledges the fnancial support by ICREA under the ICREA Academia programme.es_ES
dc.language.isoenges_ES
dc.publisherNaturees_ES
dc.relationinfo:eu-repo/grantAgreement/EC/FP7/340918es_ES
dc.relationinfo:eu-repo/grantAgreement/MICIU/FPU17/01925es_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.subjectbeverageses_ES
dc.subjectteaes_ES
dc.subjectglomerular filtration ratees_ES
dc.subjectepidermal growth factor receptorses_ES
dc.subjectepidemiologyes_ES
dc.subjectcaffeinees_ES
dc.subjectcoffeees_ES
dc.subjectregression analysises_ES
dc.subjectobesityes_ES
dc.subjectoverweightes_ES
dc.subjectmetabolic syndromees_ES
dc.subjectpopulation declinees_ES
dc.subjectmetabolic disorderses_ES
dc.subjectkidneyses_ES
dc.subjectbody weightes_ES
dc.subjectcreatininees_ES
dc.subjectkidney diseaseses_ES
dc.titleConsumption of Caffeinated Beverages and Kidney Function Decline in an Elderly Mediterranean Population with Metabolic Syndromees_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.holderThis work is published under http://creativecommons.org/licenses/by/4.0/ License (CC BY 4.0)es_ES
dc.rights.holderAtribución 3.0 España*
dc.relation.publisherversionhttps://www-proquest-com.ehu.idm.oclc.org/docview/2516596486/abstract/C2BB4656CB8F4B91PQ/1?accountid=17248es_ES
dc.identifier.doi10.1038/s41598-021-88028-7
dc.contributor.funderEuropean Commission
dc.departamentoesMedicinaes_ES
dc.departamentoeuMedikuntzaes_ES


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