Multilevel responses of adult zebrafish to crude and chemically dispersed oil exposure
dc.contributor.author | Esteban Sánchez, Ada | |
dc.contributor.author | Johann, Sarah | |
dc.contributor.author | Bilbao Alemany, Dennis | |
dc.contributor.author | Prieto Sobrino, Ailette | |
dc.contributor.author | Hollert, Henner | |
dc.contributor.author | Seiler, Thomas-B. | |
dc.contributor.author | Orbea del Rey, Amaia | |
dc.date.accessioned | 2021-10-28T12:25:02Z | |
dc.date.available | 2021-10-28T12:25:02Z | |
dc.date.issued | 2021-12 | |
dc.identifier.citation | Environmental Sciences Europe 33(1) : (2021) // Article ID 106 | es_ES |
dc.identifier.issn | 2190-4707 | |
dc.identifier.issn | 2190-4715 | |
dc.identifier.uri | http://hdl.handle.net/10810/53669 | |
dc.description.abstract | Background The application of chemical dispersants is a common remediation strategy when accidental oil spills occur in aquatic environments. Breaking down the oil slick into small droplets, dispersants facilitate the increase of particulate and dissolved oil compounds, enhancing the bioavailability of toxic oil constituents. The aim of the present work was to explore the effects of water accommodated fractions (WAF) of a naphthenic North Sea crude oil produced with and without the addition of the chemical dispersant FINASOL OSR 52 to adult zebrafish exposed for 3 and 21 d. Fish were exposed to environmentally relevant concentrations of 5% and 25% WAF(OIL) (1:200) and to 5% WAF(OIL+D) (dispersant-oil ratio 1:10) in a semi-static exposure setup. Results The chemically dispersed WAF presented a 20-fold increase of target polycyclic aromatic hydrocarbons (PAHs) in the water phase compared to the corresponding treatment without dispersant and was the only treatment resulting in markedly bioaccumulation of PAHs in carcass after 21 d compared to the control. Furthermore, only 5% WAF(OIL+D) caused fish mortality. In general, the undispersed oil treatments did not lead to significant effects compared to control, while the dispersed oil induced significant alterations at gene transcription and enzyme activity levels. Significant up-regulation of biotransformation and oxidative stress response genes (cyp1a, gstp1, sod1 and gpx1a) was recorded in the livers. For the same group, a significant increment in EROD activity was detected in liver along with significant increased GST and CAT activities in gills. The addition of the chemical dispersant also reduced brain AChE activity and showed a potential genotoxic effect as indicated by the increased frequency of micronuclei in erythrocytes after 21 d of exposure. Conclusions The results demonstrate that the addition of chemical dispersants accentuates the effect of toxic compounds present in oil as it increases PAH bioavailability resulting in diverse alterations on different levels of biological organization in zebrafish. Furthermore, the study emphasizes the importance to combine multilevel endpoints for a reliable risk assessment due to high variable biomarker responses. The present results of dispersant impact on oil toxicity can support decision making for oil spill response strategies. | es_ES |
dc.description.sponsorship | Open Access funding enabled and organized by Projekt DEAL. The present study was funded by EU H2020-BG-2005-2 project GRACE (grant agreement #679266), Spanish MINECO (NACE project CTM2016-81130-R) and MECD (FPU16/01837 grant to A.E.), Basque Government (consolidated research groups IT810-13, IT1302-19, IT1213-19). Document | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.relation | info:eu-repo/grantAgreement/EC/H2020/679266 | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/CTM2016-81130-R | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.subject | bioaccumulation | es_ES |
dc.subject | biomarkers | es_ES |
dc.subject | biotransformation | es_ES |
dc.subject | chemical dispersants | es_ES |
dc.subject | crude oil | es_ES |
dc.subject | genotoxicity | es_ES |
dc.subject | oil spills | es_ES |
dc.subject | oxidative stress | es_ES |
dc.subject | water accommodated fractions | es_ES |
dc.subject | zebrafish | es_ES |
dc.subject | polycyclic aromatic-hydrocarbons | es_ES |
dc.subject | water-soluble fraction | es_ES |
dc.subject | glutathione s-transferases | es_ES |
dc.subject | short-term exposure | es_ES |
dc.subject | antioxidant responses | es_ES |
dc.subject | danio-rerio | es_ES |
dc.subject | developmental toxicity | es_ES |
dc.subject | oxidative stress | es_ES |
dc.subject | accommodated fractions | es_ES |
dc.subject | phenanthrene exposure | es_ES |
dc.title | Multilevel responses of adult zebrafish to crude and chemically dispersed oil exposure | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. | es_ES |
dc.rights.holder | Atribución 3.0 España | * |
dc.relation.publisherversion | https://enveurope.springeropen.com/articles/10.1186/s12302-021-00545-4 | es_ES |
dc.identifier.doi | 10.1186/s12302-021-00545-4 | |
dc.contributor.funder | European Commission | |
dc.departamentoes | Química analítica | es_ES |
dc.departamentoes | Zoología y biología celular animal | es_ES |
dc.departamentoeu | Kimika analitikoa | es_ES |
dc.departamentoeu | Zoologia eta animalia zelulen biologia | es_ES |
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