dc.contributor.author | Velasco Lozano, Susana | |
dc.contributor.author | Alonso de Castro, Silvia | |
dc.contributor.author | Sánchez Cano, Carlos | |
dc.contributor.author | Benítez Mateos, Ana I. | |
dc.contributor.author | López Gallego, Fernando | |
dc.contributor.author | Salassa, Luca | |
dc.date.accessioned | 2022-02-11T08:48:55Z | |
dc.date.available | 2022-02-11T08:48:55Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Chemical Science 13(1) : 59-67 (2022) | es_ES |
dc.identifier.issn | 2041-6520 | |
dc.identifier.issn | 2041-6539 | |
dc.identifier.uri | http://hdl.handle.net/10810/55433 | |
dc.description.abstract | [EN] Catalysis-based approaches for the activation of anticancer agents hold considerable promise. These principally rely on the use of metal catalysts capable of deprotecting inactive precursors of organic drugs or transforming key biomolecules available in the cellular environment. Nevertheless, the efficiency of most of the schemes described so far is rather low, limiting the benefits of catalytic amplification as strategy for controlling the therapeutic effects of anticancer compounds. In the work presented here, we show that flavin reactivity within a hydrogel matrix provides a viable solution for the efficient catalytic activation and delivery of cisplatin, a worldwide clinically-approved inorganic chemotherapy agent. This is achieved by ionically adsorbing a flavin catalyst and a Pt(iv) prodrug as substrate into porous amino-functionalized agarose beads. The hydrogel chassis supplies high local concentrations of electron donating groups/molecules in the surrounding of the catalyst, ultimately boosting substrate conversion rates (TOF >200 min(-1)) and enabling controlled liberation of the drug by light or chemical stimuli. Overall, this approach can afford platforms for the efficient delivery of platinum drugs as demonstrated herein by using a transdermal diffusion model simulating the human skin. | es_ES |
dc.description.sponsorship | We acknowledge financial support from the Spanish State Research Agency (grants CTQ2016-80844-R, PID2019-109111RBI00, RTI2018-094398-B-I00, BIO2014-61838-EXP) and the Basque Government (Eusko Jaurlaritza, grant PIBA_2021_1_0034). S. V. L. thanks the Mexican Council of Science and Technology (CONACyT) for the postdoctoral fellowship she received (ref. CVU-267390). C. S. C. thanks Gipuzkoa Foru Aldundia (Gipuzkoa Fellows program; grant number 2019-FELL-000018-01/62/2019) for.nancial support. L. S. thanks the Spanish MultiMetDrugs network (RED2018-102471-T) for fruitful discussion. FLG thanks the Spanish Biocatalysis network (RED2018-102403T) and the European Research Council (ERC-Co-2018 818089). This work was performed under the Maria de Maeztu and Severo Ochoa Centres of Excellence Programme run by the Spanish State Research Agency, Grant No. MDM-2017-0720 (CIC biomaGUNE) and CEX2018-000867-S (DIPC). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Royal Society of Chemistry | es_ES |
dc.relation | info:eu-repo/grantAgreement/EC/H2020/818089 | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/CTQ2016-80844-R | es_ES |
dc.relation | info:eu-repo/grantAgreement/MICINN/PID2019-109111RBI00 | es_ES |
dc.relation | info:eu-repo/grantAgreement/MICIU/RTI2018-094398-B-I00 | es_ES |
dc.relation | info:eu-repo/grantAgreement/MICIU/MDM-2017-0720 | es_ES |
dc.relation | info:eu-repo/grantAgreement/MICIU/CEX2018-000867-S | es_ES |
dc.relation | info:eu-repo/grantAgreement/MICIU/RED2018-102471-T | es_ES |
dc.relation | info:eu-repo/grantAgreement/MICIU/RED2018-102403T | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/3.0/es/ | * |
dc.subject | bioorthogonal catalysis | es_ES |
dc.subject | activation | es_ES |
dc.subject | progress | es_ES |
dc.title | Metal substrate catalysis in the confined space for platinum drug delivery | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | © 2022 The Author(s). Published by the Royal Society of Chemistry. This article is licensed under a Creative Commons Attribution Non Commercial 3.0 unported licence. | es_ES |
dc.rights.holder | Atribución-NoComercial 3.0 España | * |
dc.relation.publisherversion | https://pubs.rsc.org/en/content/articlelanding/2022/SC/D1SC05151B | es_ES |
dc.identifier.doi | 10.1039/d1sc05151b | |
dc.contributor.funder | European Commission | |