dc.contributor.author | Baciero Hernández, Inés | |
dc.contributor.author | Musatadi Larrucea, Mikel | |
dc.contributor.author | Olivares Zabalandikoetxea, Maitane | |
dc.contributor.author | Prieto Sobrino, Ailette | |
dc.contributor.author | Etxebarria Loizate, Nestor | |
dc.contributor.author | Zuloaga Zubieta, Olatz | |
dc.date.accessioned | 2024-04-16T15:01:04Z | |
dc.date.available | 2024-04-16T15:01:04Z | |
dc.date.issued | 2023-11-29 | |
dc.identifier.citation | MethodsX 12 : (2024) // Article ID 102501 | es_ES |
dc.identifier.issn | 2215-0161 | |
dc.identifier.uri | http://hdl.handle.net/10810/66707 | |
dc.description.abstract | The concept of exposome covers all the exposures an individual suffers from conception to death,
which can be partially assessed through the monitoring of human biofluids. In there, target ana-
lytical approaches tend to focus on a limited set of xenobiotics, whereas exposomic studies need
broad scopes in search of a full understanding. Given the issue, suspect and non-target screen-
ing are feasible alternatives. However, adequate sample preparation procedures should minimize
interferences without significantly reducing the number of xenobiotics. Within this context, the
present article aims to describe comprehensive sample preparation procedures for suspect or non-
target screening of organic xenobiotics in several human biofluids, all coupled to unified separa-
tion and detection conditions based on ultra-high performance liquid chromatography-high res-
olution tandem mass spectrometry (UHPLC–HRMS/MS) | es_ES |
dc.description.sponsorship | This work was financially supported by the State Research Agency of the Ministry of Science and Innovation (Government of Spain) through project PID 2020-117686RB-C31 and the Basque Government as a consolidated group of the Basque Research System (IT-1446-22). Inés Baciero-Hernández and Mikel Musatadi acknowledge the Basque Government for their predoctoral fellowships. Illustrations for the graphical abstract were taken from Flaticon. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.relation | info:eu-repo/grantAgreement/MCIN/PID 2020-117686RB-C31 | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ | * |
dc.subject | human exposome | es_ES |
dc.subject | biomonitoring | es_ES |
dc.subject | extraction and clean-up | es_ES |
dc.subject | LC-HRMS/MS analysis | es_ES |
dc.subject | urine | es_ES |
dc.subject | breast milk | es_ES |
dc.subject | saliva | es_ES |
dc.subject | follicular fluid | es_ES |
dc.title | Sample preparation for suspect and non-target screening of xenobiotics in human biofluids by liquid chromatography —High resolution tandem mass spectrometry | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | © 2023 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license | es_ES |
dc.relation.publisherversion | https://www.sciencedirect.com/science/article/pii/S2215016123004971 | es_ES |
dc.identifier.doi | 10.1016/j.mex.2023.102501 | |
dc.departamentoes | Química analítica | es_ES |
dc.departamentoeu | Kimika analitikoa | es_ES |