Effectiveness of antidepressants in improving the prognosis of COVID-19: A systematic review and meta-analysis
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Date
2024Author
Cobos Campos, Raquel
Sáez De La Fuente Moriñigo, Arantza
Cordero Guevara, José Aurelio
Bermúdez Ampudia, Cristina
Parraza Díez, Naiara
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Atención Primaria 56 : (2024) // Article ID 102771
Abstract
Objective,
and
material
and
methods:
A
systematic
review
and
meta-analysis
was
performed
to
evaluate
the
effectiveness
of
antidepressants
in
reducing
the
poor
evolution
of
COVID-19
disease
(a
composite
variable
including
death,
hospitalization
and
need
for
mechanical
ventila-
tion),
and
mortality,
according
the
guidelines
for
Systematic
Reviews
of
Interventions
published
by
the
Cochrane
library.
Source
of
data:
MEDLINE,
EMBASE
and
COCHRANE
LIBRARY
were
consulted
up
to
February
25,
2022.
Unpublished
studies
were
searched
on
clinicaltrials.gov
platform.
Selection
of
studies:
Seven
masked
and
unmasked,
observational
and
experimental
studies
evaluating
death,
hospitalization
and
need
for
mechanical
ventilation
were
selected.
A
second
subgroup
analysis
with
mortality
variable
was
performed.
Data
extraction:
A
full
risk
of
bias
assessment
was
performed
addressing
issues
such
as
informa-
tion
and
confounding
bias.
ROB2
and
Robins-I
tools
for
randomized
and
no
randomized
studies
were
employed
respectively.
In
the
quantitative
analysis,
the
risk
of
publication
bias,
hetero-
geneity,
estimation
of
pooled
measure
and
a
sensitivity
analysis
was
performed.
The
pooled
final
measure
was
calculated
as
odds
ratio
with
its
correspondent
95%
confidence
interval.
A
random
effects
model
was
used
for
this
purpose
due
to
the
heterogeneity
between
included
studies.
Finally,
a
sensitivity
analysis
was
performed
to
assess
the
robustness
of
final
pooled
measure.
Results:
Seven
studies
were
finally
considered
to
calculate
the
final
pooled
measure.
The
effect
of
intervention
was
OR
0.73;
95%
CI
0.56---0.94.