dc.contributor.author | Cobos Campos, Raquel | |
dc.contributor.author | Sáez De La Fuente Moriñigo, Arantza | |
dc.contributor.author | Cordero Guevara, José Aurelio | |
dc.contributor.author | Bermúdez Ampudia, Cristina | |
dc.contributor.author | Apiñaniz Fernández de Larrinoa, Antxon | |
dc.contributor.author | Parraza Díez, Naiara | |
dc.date.accessioned | 2024-04-22T17:21:24Z | |
dc.date.available | 2024-04-22T17:21:24Z | |
dc.date.issued | 2024 | |
dc.identifier.citation | Atención Primaria 56 : (2024) // Article ID 102771 | es_ES |
dc.identifier.issn | 1578-1275 | |
dc.identifier.uri | http://hdl.handle.net/10810/66850 | |
dc.description.abstract | Objective,
and
material
and
methods:
A
systematic
review
and
meta-analysis
was
performed
to
evaluate
the
effectiveness
of
antidepressants
in
reducing
the
poor
evolution
of
COVID-19
disease
(a
composite
variable
including
death,
hospitalization
and
need
for
mechanical
ventila-
tion),
and
mortality,
according
the
guidelines
for
Systematic
Reviews
of
Interventions
published
by
the
Cochrane
library.
Source
of
data:
MEDLINE,
EMBASE
and
COCHRANE
LIBRARY
were
consulted
up
to
February
25,
2022.
Unpublished
studies
were
searched
on
clinicaltrials.gov
platform.
Selection
of
studies:
Seven
masked
and
unmasked,
observational
and
experimental
studies
evaluating
death,
hospitalization
and
need
for
mechanical
ventilation
were
selected.
A
second
subgroup
analysis
with
mortality
variable
was
performed.
Data
extraction:
A
full
risk
of
bias
assessment
was
performed
addressing
issues
such
as
informa-
tion
and
confounding
bias.
ROB2
and
Robins-I
tools
for
randomized
and
no
randomized
studies
were
employed
respectively.
In
the
quantitative
analysis,
the
risk
of
publication
bias,
hetero-
geneity,
estimation
of
pooled
measure
and
a
sensitivity
analysis
was
performed.
The
pooled
final
measure
was
calculated
as
odds
ratio
with
its
correspondent
95%
confidence
interval.
A
random
effects
model
was
used
for
this
purpose
due
to
the
heterogeneity
between
included
studies.
Finally,
a
sensitivity
analysis
was
performed
to
assess
the
robustness
of
final
pooled
measure.
Results:
Seven
studies
were
finally
considered
to
calculate
the
final
pooled
measure.
The
effect
of
intervention
was
OR
0.73;
95%
CI
0.56---0.94. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ | * |
dc.subject | selective serotonin reuptake inhibitors | es_ES |
dc.subject | antidepressants | es_ES |
dc.subject | Covid-19 | es_ES |
dc.title | Effectiveness of antidepressants in improving the prognosis of COVID-19: A systematic review and meta-analysis | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | ©
2023
The
Authors.
Published
by
Elsevier
España,
S.L.U.
This
is
an
open
access
article
under
the
CC
BY-NC-ND
license
(
http://
creativecommons.org/licenses/by-nc-nd/4.0/
) | es_ES |
dc.rights.holder | Atribución-NoComercial-SinDerivadas 3.0 España | * |
dc.relation.publisherversion | https://www.elsevier.es/es-revista-atencion-primaria-27-articulo-effectiveness-antidepressants-in-improving-prognosis-S0212656723002044 | es_ES |
dc.identifier.doi | 10.1016/j.aprim.2023.102771 | |
dc.departamentoes | Medicina preventiva y salud pública | es_ES |
dc.departamentoeu | Prebentzio medikuntza eta osasun publikoa | es_ES |