Resumen
Evidence indicates that chronic social stress plays a significant role in the development of
cancer and depression. Although their association is recognized, the precise physiological mechanism
remains unknown. In our previous work, we observed that OF1 males subjected to chronic social de-
fiance exhibited anhedonia, and those who developed tumors in the lung showed anxiety-associated
behaviors. In this study, we observed that tumor-bearing OF1 mice presented higher levels of 3-HK,
and this increase may be due to IDO. No differences in hippocampal catecholamine levels were ob-
served. Our results suggest that a systemic tumor can induce molecular changes in the hippocampal
kynurenine pathway that may impact behavior.