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Identificación of ERBB4 and SOX1 role in central nervous system tumors. Implication in medulloblastoma and glioblastoma.
(2020-12-16)
Los tumores cerebrales, como el glioblastoma (GBM) en adultos y el meduloblastoma (MB) en niños, representan uno de los retos más importantes de la medicina actual, ya que resisten a las terapias disponibles, recurren y ...
Optimization of the Bioactivation of Isoflavones in Soymilk by Lactic Acid Bacteria
(MDPI, 2021-05-28)
Soybeans and soy-based products contain isoflavones which can be used for nutraceutical and medical applications. In soybeans and in unfermented soy foods, isoflavones are normally present as glycosides. Isoflavone glycosides ...
Structural Characterization of the ICOS/ICOS-L Immune Complex Reveals High Molecular Mimicry by Therapeutic Antibodies
(Nature, 2020-10-08)
The inducible co-stimulator (ICOS) is a member of the CD28/B7 superfamily, and delivers a positive co-stimulatory signal to activated T cells upon binding to its ligand (ICOS-L). Dysregulation of this pathway has been ...
Characterization of the biological and molecular activity of PML in breast cancer
(2020-11-23)
Oncogene addiction postulates that the survival and growth of certain tumor cells is dependent upon the activity of one oncogene, despite their multiple genetic and epigenetic abnormalities. This phenomenon provides a ...
Estudio de la heterogeneidad histopatológica, genética y molecular en correlación con las características clínicas, radiológicas y terapéuticas en el impacto del estado funcional y de la supervivencia
(2022-01-28)
IntroducciónEl Glioblastoma es el tumor más frecuente y agresivo del sistema nervioso central con un pronóstico extremadamentesombrío; más de la mitad de los pacientes fallecen al año del diagnóstico, la mayoría antes de ...
Stromal oncostatin M cytokine promotes breast cancer progression by reprogramming the tumor microenvironment
(American Society of Clinical Investigation, 2022-04-01)
[EN] The tumor microenvironment (TME) is reprogrammed by cancer cells and participates in all stages of tumor progression. The contribution of stromal cells to the reprogramming of the TME is not well understood. Here, we ...
Instauración del fundamento terapéutico de la inhibición de la vía de señalización Lefty-Smad en el Glioblastoma
(2022-04-21)
El Glioblastoma es el tumor cerebral primario más frecuente y agresivo del Sistema Nervioso Central. Presenta un pronóstico muy pobre, con una mediana de supervivencia menor a los 15 meses, y los costes en la sociedad ...
Unveiling the activation dynamics of a fold-switch bacterial glycosyltransferase by 19F NMR
(American Society for Biochemistry and Molecular Biology, 2020-07-17)
Fold-switch pathways remodel the secondary structure topology of proteins in response to the cellular environment. It is a major challenge to understand the dynamics of these folding processes. Here, we conducted an in-depth ...
Structural studies of filamentous plant viruses by cryo-electron microscopy and cryo-electron tomography
(2021-09-09)
Los virus filamentosos flexibles de plantas representan un grupo de patógenos de plantas que causan un gran impacto económico en cultivos dedicados a la agricultura. El géneropotyvirus es el más numeroso y abarca hasta un ...
Microfluidic chip with pillar arrays for controlled production and observation of lipid membrane nanotubes
(Royal Society of Chemistry, 2020-08-07)
Lipid membrane nanotubes (NTs) are a widespread template forin vitrostudies of cellular processes happening at high membrane curvature. Traditionally NTs are manufactured one by one, using sophisticated membrane ...